You're only supposed to blow the bloody doors off!

It's often said that JavaScript makes things inaccessible with a screen reader. This is not true. It is possible to do good and bad things with JavaScript (as with any other language, or even dynamite) - but it helps if you understand accessibility mechanics in the browser if you want to avoid blowing things up. Throw a little ARIA into the mix and you can really start to make things explode unintentionally!